Mastalerz L, et al. - Authors gauged the impact of systemic aspirin (acetylsalicylic acid) administration on airways PGE₂ biosynthesis in induced sputum supernatant (ISS) among subjects with Nonsteroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (NERD) or aspirin-tolerant asthma with chronic rhinosinusitis with nasal polyposis (ATA-CRSwNP), as well as healthy controls (HC). Findings suggested an association of aspirin-precipitated bronchoconstriction with a decrease in airway PGE₂ biosynthesis. The mechanism of PGE₂ biosynthesis inhibition is supported as a trigger for bronchoconstriction in NERD. Elevated sputum eosinophilic count was seen in NERD subjects as compared to ATA-CRSwNP and HC. A 2.8 times lower dose of aspirin resulted in a similar decrease of PGE₂ in NERD as in HC.