Wang YJ, Lin ET, Chen YT, et al. - Among female Asian patients with melasma, researchers compared the effectiveness and tolerance of the picosecond alexandrite laser with those of diffractive lens array (DLA) and triple combination creams (TCC: fluocinolone acetonide 0.01%, hydroquinone 4% and tretinoin 0.05%). For this investigation, 29 individuals were randomly assigned to group A1 (3 laser sessions at 4-week intervals), A2 (5 laser sessions at 4-week intervals) or B (TCC daily for at least 8 weeks and then tapered until the final evaluation). The study was completed by 9, 11 and 6 participants in groups A1, A2 and B, respectively. For the treatment of melasma, picosecond alexandrite laser treatment using DLA exhibited comparable effectiveness with TCC. Improvements have been observed in the laser groups in texture, spots, wrinkles and pores. Additional laser treatment sessions may benefit patients with melasma lesions with telangiectasia.