Roe JR, et al. - By performing this randomized, fellow eye controlled, clinical trial, researchers performed a comparison of results between wavefront-optimized (WFO) laser in situ keratomileusis (LASIK) vs high-resolution wavefront-guided (WFG) LASIK. This study included 200 eyes of 100 patients having myopia or compound myopic astigmatism receiving bilateral LASIK between October 2015 and February 2017. These had WFO LASIK in 1 eye and WFG LASIK in the fellow eye. Higher levels of supervision and better contrast sensitivity were reported for WFG LASIK vs WFO. In the WFG vs in the WFO group, they detected significantly higher mean gain in lines of corrected distance visual acuity. Significantly better contrast sensitivity for mean and frequency of attaining > 20/40 for < 5% low-contrast sensitivity and > 20/32 for < 25% low-contrast sensitivity were noted in the WFG cohort. They also found a significantly higher frequency of < 0.25 diopters (D) of refractive astigmatism at 12 months but not < 0.50 D in the WFO group. According to the findings, excellent visual outcomes were obtained with wavefront-optimized and high-resolution wavefront-guided LASIK. Nonetheless, in some regards, superior outcomes seemed to be provided by treatments based on a high-resolution aberrometer.