Leone AM, et al. - Researchers compared patients (n=350) with angiographically intermediate coronary lesions (n=446) who were randomized to fractional flow reserve (FFR) or optical coherence tomography (OCT) guidance, with respect to clinical and economic outcomes, in this prospective trial. The percutaneous coronary intervention was performed in the FFR arm if FFR was ≤0.80 striving for a postprocedure FFR >0.90. In the presence of percentage of area stenosis of ≥75% or 50% to 75% with minimal lumen area <2.5 mm² or plaque ulceration, percutaneous coronary intervention was performed in the OCT arm. A rise in the rate of patients treated with medical therapy alone was reported in relation to functional guidance by FFR vs OCT in patients with angiographically intermediate coronary lesions; this subsequently led to significant attenuation in delivered contrast, contrast-induced acute kidney injury, and total expenses at 1 month with FFR.