Druy AE, et al. - In patients with neuroblastoma detected by quantitative reverse transcription polymerase chain reaction, the applicability and prognostic significance of bone marrow (BM) involvement was investigated prospectively via assessing expression of PHOX2B, TH, ELAVL4, and B4GALNT1(GD2-synthase) in neuroblastoma cell lines, control BM samples, and in BM samples from patients. Researchers reported that PHOX2B and TH were the best markers for detection of BM involvement, which identified high-risk patients. They found that predominance of normalized expression of PHOX2B over TH > 1.68 in the diagnostic BM samples showed an adverse prognostic effect.