Prospective evaluation of the first‐trimester screening strategy for preterm preeclampsia and its clinical applicability in China
Ultrasound in Obstetrics & Gynecology Apr 08, 2021
Hu J, Gao J, Liu J, et al. - Researchers aimed at examining the performance of screening strategy for preterm preeclampsia using the Fetal Medicine Foundation (FMF)'s competing risk model in mainland China as well as determined its clinical applicability. In this prospective multicenter study, a total of 10,899 singleton pregnancies were included and measurement of mean arterial pressure (MAP), uterine artery pulsatility index (UtPI), maternal serum levels of placental growth factor (PlGF) and pregnancy associated plasma protein A (PAPPA) at 11‐13 weeks’ gestation was done and their conversion was done into multiples of median according to localized parameters; FMF's algorithm was used for calculating individualized risk stratification. Preeclampsia developed in a total of 312 pregnancies, among which 117 cases were diagnosed as preterm; severe composite placenta‐associated pregnancy outcomes, including preterm preeclampsia, complicated 386 pregnancies; 146 cases had severe small for gestational age (SGA < 3rd percentile); 61 cases had placenta abruption, and 109 cases had preterm birth delivered before 34 gestational weeks. Based on findings from this population study, they suggest the FMF's competing‐risk model for preterm preeclampsia as effective in mainland China. Women who screened as positive for preterm preeclampsia were noted to be at an elevated risk for other placenta‐associated pregnancy complications.
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