Shadyab AH, et al. - Researchers evaluated the relationships of high-sensitivity C-reactive protein (CRP) levels and polygenic CRP genetic risk scores (GRS) with the risk of end-stage hip or knee osteoarthritis (OA), defined as incident total hip (THR) or knee replacement (TKR) for OA. A cohort of postmenopausal white, African American, and Hispanic women from the Women’s Health Initiative was included in the study. Findings did not demonstrate any association of serum levels of ln hs-CRP and genetically-predicted CRP levels with risk of THR or TKR for OA among a diverse cohort of women.