Maltais M, de Souto Barreto P, Perus L, et al. - Researchers conducted a secondary analysis of the randomized controlled Multidomain Alzheimer Preventive Trial (MAPT) with the aim to estimate correlations between white matter (WM) integrity using diffusion tensor imaging and the 5-year worsening of frailty in community-dwelling older adults. At 13 memory centers in France and Monaco, recruitment of individuals (mean age = 74.7 ± 3.9 years) with no dementia at baseline who had functional MRI performed as part of the MAPT study (n = 227) was done between 2008 and 2011. They acquired fractional anisotropy and mean diffusivity (MD), axial diffusivity (AxD), and radial diffusivity (RD) for 10 different brain regions. Assessment of frailty was done by the Fried frailty phenotype (score from 0 to 5, higher is worse) at up to seven-time points for 5 years. Findings, for the first time, suggested a correlation of WM integrity with frailty in older adults. As per the analysis, the RD, AxD, and MD for different brain regions (anterior limb of internal capsule, external capsule, posterior corona radiata, posterior thalamic radiation, superior corona radiata, superior frontal occipital fasciculus, and superior longitudinal fasciculus) are significantly correlated with worsening of frailty over 5 years after adjusting for multiple comparisons.