Oki T, Aokage K, Ueda T, et al. - This study involved individuals with stage I invasive mucinous adenocarcinoma (IMA, a newly listed type of lung adenocarcinoma) (n = 99) and analyzed the relationship between the proportion of goblet cells and the clinicopathological features of IMA. The cases were categorized into two groups ie, the cases with a high goblet cell proportion (HGP, goblet cell proportion ≥80%) and the cases with a low goblet cell proportion (LGP, goblet cell proportion ≤30%). The univariate and multivariate analysis reported that for recurrence-free survival and overall survival, the goblet cell proportion was a prognostic factor. In the LGP group vs HGP group, the expression levels of the cancer stem cell-related marker, aldehyde dehydrogenase-1, and proliferation-related marker, geminin were significantly greater. In the LGP stroma, in comparison with the HGP stroma, had significantly more CD204+ tumor-associated macrophages. Therefore, this current study designated that in surgically resected IMA, the proportion of goblet cells had an association with the malignant potential.