Kulhánová I, et al. – Researchers assessed cancer burden attributable to major lifestyle and environmental risk factors in this investigation. They used age-, sex-, and site-specific incidence estimates for 2012 from IARC's GLOBOCAN, and risk factors like smoking, alcohol, high body mass index, insufficient physical activity, diet, suboptimal breastfeeding, infections and air pollution were evaluated. In the 22 countries of the Eastern Mediterranean region, researchers estimated sex-specific population-attributable fraction as per the prevalence of the selected risk factors and the relative risks obtained from meta-analyses. All selected risk factors combined contributed to nearly 33% (or 165,000 cases) of all new cancer cases in adults aged ≥ 30 years in 2012. Among men, > 50% of the total attributable cases were related to infections and smoking; among women, > 67% of the total attributable cases were related to insufficient physical activity and exposure to infections. Findings suggested that a substantial number of cancer cases in the Eastern Mediterranean could be prevented by reducing exposure to major lifestyle and environmental risk factors.