Malekmohammadi M, et al. - This study was performed to test the hypothesis that propofol-induced loss of consciousness results in functional disconnection of human sensorimotor cortices underlying the loss of volitional motor responses. Researchers observed a decrease in functional connectivity between sensory and motor cortices, despite an increase in local spectral power. They noted that this finding was suggestive of propofol causing a functional disconnection of cortices with increases in autonomous activity within cortical regions. The occurrence of this pattern was noted across diseases evaluated, this indicated that these possibly represent generalizable impacts of propofol in patients with movement disorders and beyond. In addition, the observations pointed out that sensorimotor network disruption may underlie anesthetic-induced loss of volitional control.