Balki M, Downey K, Walker A, et al. - Researchers conducted a double-blind, three-arm randomized controlled trial with the aim to determine if prophylactic administration of oxytocin plus ergonovine or oxytocin plus carboprost vs oxytocin alone is more effective in lowering the necessity for additional uterotonics among women undergoing cesarean delivery for labor arrest. They randomized 105 participants (35 per group) to receive either oxytocin 5 units intravenous alone, or with ergonovine 0.25 mg intravenous or carboprost 0.25 mg intramuscular immediately after delivery, followed with maintenance infusion of oxytocin 40 milliunits/minute in all groups. Data from 100 participants were included in analysis. No reduction in the need for additional uterotonics at cesarean delivery for labor arrest was observed in correlation with prophylactic use of a combination of uterotonic drugs compared with oxytocin alone.