Zhang H, et al. - Researchers investigated whether prolyl-4-hydroxylase α subunit 2 (P4HA2) has prognostic significance in epithelial ovarian cancer (EOC) cases. They obtained 217 clinical samples (EOC tissues, 167 cases; normal ovarian, 50 cases) and these were pathologically verified employing hematoxylin and eosin staining. Using immunohistochemistry (IHC), P4HA2 expression in clinical samples was stained. Significant upregulation of P4HA2 in EOC tissues vs normal tissues was revealed by IHC staining. A significant link of high P4HA2 expression with worse progression-free survival as well as overall survival was seen both in clinical samples and Kaplan–Meier Plotter database. Thus, an association between P4HA2 expression and clinical outcome in EOC was preliminarily proved in this study. Findings indicate that P4HA2 might represent not only a prognostic factor for EOC progression but also a likely valuable treatment target for EOC.