Lorimier G, et al. - From 2005 to 2016, researchers analyzed 150 patients who underwent complete cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) with or without prolonged perioperative thoracic epidural analgesia (PEA) for colorectal peritoneal metastases (CPM) in order to determine the effectiveness of prolonged perioperative PEA on long-term survival of these patients. Outcomes of this retrospective study suggest that the perioperative thoracic epidural analgesia prolonged for over 72 hours reduced significantly the grade III-IV morbidity and may improve overall survival and disease free survival.