Sheth DS, Ho N, Pio JR, et al. - This study was intended to distinguish clinical and psychological risk factors correlated with prolonged opioid use. Researchers performed a prospective study to obtain psychological profile data preoperatively. After 90 days, prolonged use was characterized as dispensation of an opioid. They applied logistic regressions for univariate and multivariate modellings and to develop receiver operating characteristic curves. They applied a backward stepwise regression analysis to select significant factors in the multivariable model. A total of 258 patients were included in the study (163 TKR, 95 THR). It was shown that preoperative opioid use was the strongest predictor of postoperative prolonged opioid use. Younger age, correlated back pain, and chronic pain syndrome were the other distinguished risk factors. The findings revealed that screening tools to diagnose ADRB may be more beneficial than those for depression or pain catastrophizing.