Bai X, Zhou C, Guo T, et al. - This study was carried out to investigate the microstructural alterations in subcortical nuclei in Parkinson's disease (PD) at different stages with diffusion kurtosis imaging (DKI) and tensor imaging and to test the performance of diffusion metrics in identifying PD. Researchers recruited a total of 108 PD patients (64 patients in early-stage PD group and 44 patients in moderate-late-stage PD group) and 64 healthy controls. They compared tensor and kurtosis metrics in the subcortical nuclei. The diagnostic performance of the diffusion metrics was investigated using logistic regression and receiving operator characteristic analysis. As per the findings, PD has progressive microstructural alterations in the subcortical nuclei. During PD progression, DKI is sensitive to detect microstructural alterations in globus pallidus and thalamus. It has been considered that combining kurtosis and tensor metrics can achieve a good performance in diagnosing PD.