Steinkohl E, Olesen SC, Mark EB, et al. - The present study was undertaken to evaluate and investigate the potential role of structural magnetic resonance imaging (MRI) biomarkers for characterization of disease progression in a CP individual cohort over a 4-year period. Researchers designed a longitudinal MRI study that enrolled a total of 25 individuals with definitive CP. Evaluations of morphological imaging parameters at baseline and after 4 years involved pancreatic gland volume, apparent diffusion coefficient (ADC) values, the fat signal fraction (FSF) and main pancreatic duct (MPD) diameter. Individuals were divided according to the modified Cambridge classification. In individuals with established CP, morphological progression appears to be primarily parenchymal-related. It was demonstrated that the different parenchymal alterations were mostly unrelated and apparently reflect diverse pathophysiological processes.