van Wijngaarden SE, et al. - A sum of 234 subjects were quantified to delineate the progress of left ventricular myocardial dysfunction in systemic sclerosis (SSc) cases. They estimated the left ventricular (LV) systolic function with global longitudinal strain (GLS) by echocardiographic speckle-tracking analysis. They noticed no change in LV ejection fraction (62% ± 7 vs 61% ± 8) whereas GLS had significantly worsened (−21% ± 2 vs −19% ± 2) at follow-up. They found proximal muscle weakness, DLCO, and LV diastolic dysfunction helpful in identifying subjects at risk for progressive LV systolic dysfunction and in need of closer cardiac monitoring.