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Progression of coronary atherosclerotic plaque burden and relationship with adverse cardiovascular event in asymptomatic diabetic patients

BMC Cardiovascular Disorders Feb 16, 2019

Yang J, et al. - In asymptomatic diabetic patients, researchers determined coronary plaque progression and its influence on cardiac events in this retrospective longitudinal follow-up study. Data analysis was carried out for 197 asymptomatic patients (63.1 ± 17 years, 60% males) with diabetes mellitus (DM) and suspected coronary artery disease (CAD) who had clinically indicated dual-source cardiac computed tomography (CT). Using CT coronary artery calcium scores (CACS), patients were grouped as those with CACS> 10 and those with CACS≤10. They analyzed follow-up data from medical records, and cardiac events in relation to plaque composition and progression were noted. Plaque progression as well as progression to “overt or silent CAD” was found in asymptomatic patients with DM. Findings revealed a link between the relative increase in plaque volume and subsequent cardiac events. Also, an inverse correlation was noted between coronary calcification and outcome in asymptomatic diabetic patients.

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