Phonwijit L, et al. - In the study presented here, progression-free survival (PFS) and factors associated with postoperative recurrence were investigated in patients with atypical meningioma. According to the findings obtained, tumor location and pial invasion were significantly associated with increased incidence of tumor recurrence. In addition, postoperative radiation therapy (RT) was found to be significantly correlated with decreased tumor progression and recurrence.

Methods

• During the 2004 to 2014, patients diagnosed with atypical menigioma who underwent surgery at Siriraj Hospital were included in this investigation.
• Features potentially related to PFS and tumor recurrence from clinical records, operative records, and neuroimaging studies were assessed and analyzed.

Results

• 126 patients with mean age of 55 years were incorporated.
• Researchers reported that median PFS was 55 months.
• They observed that 5-year and 10-year PFS rate was 72.5% and 32%, respectively.
• They noted that median follow-up duration was 52 months.
• In multivariate analysis, tumor location (convexity, parasagittal/falcine, intraventricular, skull base) (p=0.003) and pial invasion (HR: 2.02; p=0.045) were significantly related to tumor recurrence.
• Findings revealed that postoperative RT was related to reduction in tumor recurrence in both univariate (OR: 0.48; p=0.039) and multivariate analysis (HR: 0.42; p=0.005).