Tessier-Cloutier B et al. - In the current study, it was shown that there is an inverse relationship between PD-L1 expression and disease-specific survival times in resected pancreatic ductal adenocarcinoma (PDAC).

Methods
A tissue microarray was constructed from cases of resected PDAC.
PD-L1 immunohistochemistry was performed using the SP142 primary antibody.
Immunohistochemical assessment for deficient mismatch repair status (MMRd), CD3, and CD8 was performed.

Results
252 PDAC speciments were assessed.
31, 17, and 12 speciments were positive at percentage cut-offs of greater tha 0, greater than 5, and greater than 10%, respectively.
Increased PD-L1 expression was associated with inferior prognosis.
No association existed between PD-L1 status and MMR status or tumor infiltrating lymphocytes.