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Prognostic values of baseline, interim and end-of therapy 18F-FDG PET/CT in patients with follicular lymphoma

Cancer Management and Research Jul 27, 2019

Zhou Y, et al. - Researchers conducted the present study to determine the role of baseline, interim and end-of treatment positron emission tomography/computed tomography (PET/CT) in evaluating the prognosis of follicular lymphoma (FL). They retrospectively analyzed 84 FL patisnts and re-evaluated baseline (n=59), interim (n=24, after 2–4 cycles) and end-of treatment (n=43) PET/CT images and recorded baseline maximum standardized uptake value (SUVmax), total metabolic tumor volume and total lesion glycolysis (TLG) were recorded. Analysis indicated a significant correlation of the baseline TLG and end-of treatment PET (E-PET) results with prognosis in patients with FL. E-PET results using Deauville five-point scale (D-5PS) and International Harmonization Project criteria (IHP) criteria were identified as statistically significant. The D-5PS vs IHP criteria showed stronger prognostic value. According to interim-PET, ΔSUVmax% had optimal cutoff value of 66.95% and according to E-PET, it was 68.97%. However, statistically significant results in the prediction of PFS were achieved only with the ΔSUVmax% from the baseline to the end-of therapy.
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