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Prognostic value of tumor size and minimal extrathyroidal extension in papillary thyroid carcinoma

American Journal of Surgery Feb 24, 2020

Shin CH, Roh JL, Song DE, et al. - Researchers examined how tumor size and extrathyroidal extension (ETE) are associated with posttreatment recurrence in papillary thyroid carcinoma (PTC) patients. They assessed a total of 2,902 patients who underwent thyroidectomy for previously untreated T1–T3 PTC (7th edition American Joint Committee on Cancer) at their tertiary referral center. Among these, 1,382 (47.6%) showed minimal ETE and 329 (11.3%) showed macroscopic ETE. They identified a significant association of ETE with adverse pathological tumor findings and nodal findings. Univariate analyses revealed the association of tumor size and ETE with recurrence-free survival (RFS). Multivariate analysis suggested tumor size > 4 cm, but not ETE, as the independent factor of RFS. Only a modest decrease in RFS was observed with minimal or macroscopic ETE compared with tumor size.
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