• Profile
Close

Prognostic value of serum uric acid and tumor response to induction chemotherapy in locally advanced nasopharyngeal carcinoma

BMC Cancer May 12, 2021

Xu Y, Wu Z, Ye W, et al. - In this retrospective analysis, researchers analyzed locally advanced nasopharyngeal carcinoma (LANPC) patients receiving induction chemotherapy (IC) followed by concurrent chemoradiation therapy (CCRT), to determine the combined predictive value of serum uric acid (SUA) and tumor response to IC in this population. Participants included 341 LANPC cases managed with IC + CCRT. In multivariable analysis, SUA concentration following two cycles of IC was revealed as an independent prognostic factor for overall survival (OS) but of borderline significance for progression-free survival (PFS) and distant metastasis-free survival (DMFS). A better OS, PFS, and DMFS was noted in LANPC patients with satisfactory tumor response and a high SUA level following two cycles of IC, relative to those with unsatisfactory tumor response and a low SUA level. Overall, predictive value of SUA level as well as tumor response to two cycles of IC was evident for LANPC patients managed with IC plus CCRT. For patients with a low SUA concentration and unsatisfactory tumor response to two cycles of IC, more aggressive treatment strategies are advised.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay