Li Y, Wang T, Haines P, et al. - The present study was conducted to investigate if right ventricular (RV) longitudinal strain (LS) served a superior estimation of RV systolic performance and prognostic information compared with other strain vectors. In this study, fifty-four treatment-naïve patients with pulmonary arterial hypertension (PAH) and 35 normal controls were prospectively examined. Individuals with PAH had undergone echocardiography, cardiac magnetic resonance (CMR) imaging, 6-minute walking tests, and right-sided cardiac catheterization before and six months after vasodilator therapy. Via 2D and 3D STE, the 2D LS, 3D LS, circumferential strain, and radial strain of RV free wall were estimated. They obtained RV ejection fraction from CMR. Individuals with PAH exhibit decreased RV strain. The data indicate that two-dimensional and 3D LS can track clinical improvement following vasodilator therapy and give valuable prognostic information.