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Prognostic value of right ventricular dysfunction in patients with al amyloidosis: Comparison of different techniques by cardiac magnetic resonance

Journal of Magnetic Resonance Imaging Jul 24, 2020

Wan K, Lin J, Guo X, et al. - A single‐center, prospective study was performed to evaluate the prognostic value of various measures of right ventricular (RV) function in a bid to find which best predicts outcome in amyloid light‐chain (AL) amyloidosis. Researchers examined a total of 129 patients (mean age, 58 ± 11 years; 61.2% men) with biopsy‐proven AL amyloidosis. They further assessed RV ejection fraction (EF), RV fractional area change (FAC), RV long axis strain (LAS), RV free wall longitudinal strain (FWS), RV global longitudinal strain (GLS), and tricuspid annular plane systolic excursion (TAPSE). Mann–Whitney ‐tests, Student's ‐tests, receiver‐operating characteristic curves, Kaplan–Meier curves, Cox proportional hazards regression models, and C‐statistics were applied for the evaluation. It was shown that in patients with AL amyloidosis, RV dysfunction seems to be an independent determinant of outcome. It was reported that RVFWS is a better prognosticator of all‐cause mortality than RVEF, RVFAC, or RVGLS.

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