Abdalla TSA, Meiners J, Riethdorf S, et al. - Whether preoperative circulating tumor cells (CTCs) have prognostic relevance in patients who had resection with curative intent of different stages (Union of International Cancer Control: UICC I-IV) of colorectal cancer (CRC), was inquired by using the Cellsearch system. This study included 68 of 91 patients who underwent colorectal resection. Immediately prior to surgery, CTC analysis was conducted in patients with CRC UICC stages I-IV. Researchers correlated data with clinicopathological parameters as well as with patient outcomes. They found presence of ≥ 1 CTCs/ 7.5ml correlated with distant overt metastases presence and also with shorter progression-free and overall survival. Overall, CTCs detection was revealed as an independent as well as strong prognostic factor in CRC.