Gou B, et al. - Researchers retrospectively assessed the link between preoperative mean platelet volume to plateletcrit (MPV/PCT) ratio and prognosis in 188 consecutive osteosarcoma patients who had received neoadjuvant chemotherapy and surgical resection of tumor. They used the Kaplan–Meier analysis and Cox regression proportional hazard model. Findings revealed a significant association of MPV/PCT ratio with platelet count, platelet distribution width, and PCT. A prolonged disease-free survival (DFS, P=0.035) was observed in relation to a high MPV/PCT ratio (≥43.58), in Kaplan–Meier analysis. Better DFS in the overall population was independently predicted only by good chemotherapy response, as revealed in the multivariate Cox. For a favorable prognosis in male osteosarcoma patients, the possible ability of high preoperative MPV/PCT ratio to serve as an independent prognostic factor was suggested.