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Prognostic value of inflammatory biomarkers in gastric cancer patients and the construction of a predictive model

Digestive Surgery Nov 16, 2018

Ma M, et al. - As inflammation promotes cancer development, researchers evaluated inflammatory biomarkers for their prognostic significance in gastric cancer (GC). For this study, they identified 1,227 of 2,334 patients who underwent gastrectomy for GC at Fudan University Shanghai Cancer Center between 2003 and 2007, as eligible. Analysis of preoperative serum neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio (LMR), and albumin/globulin ratio (AGR) levels was performed. Using the Cox proportional hazards regression model, they constructed a nomogram in the training set (n = 818) to predict the probability of overall survival and disease-free survival. In GC patients, a more accurate prognostic prediction after gastrectomy was made with the nomogram, suggesting its great clinical value.
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