De Luca A, Stolfo D, Caiffa T, et al. - Thirty-three patients with stable heart failure (HF) who were participants for percutaneous edge-to-edge mitral valve repair (PMVR) were prospectively recruited in order to examine the potential role of the global longitudinal strain- (GLS-) based left ventricular contractile reserve (LVCR) at dobutamine stress echocardiography (DSE) in this setting. All patients underwent DSE to evaluate LVCR. Following DSE, a positive LVCR_{left ventricular ejection fraction}, positive LVCR_GLS, and positive LVCR_{stroke volume} were discovered in 21, 12, and 14 patients, respectively. LVCR_GLS was correlated with superior symptom relief, MR improvement, and LV reverse remodeling in a short-term follow-up. An important betterment of GLS during DSE, along with history of HF hospitalization and beta-blocker therapy, was independently correlated with the risk of death/heart transplantation/HF-associated hospitalizations. Thus, LVCR, in the setting of advanced HF, evaluated by speckle-tracking DSE, is correlated with superior outcomes following PMVR. Advancement of longitudinal function emerged, beyond the ejection fraction, as an independent predictor of outcomes and could enhance the choice of best candidates for the percutaneous emendation of functional MR.