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Prognostic value of CT attenuation and FDG uptake of adipose tissue in patients with pancreatic adenocarcinoma

Clinical Radiology Dec 08, 2018

Lee JW, et al. - In patients with pancreatic adenocarcinoma, researchers retrospectively analyzed the prognostic value of computed tomography (CT) attenuation and 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) uptake in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) to predict the overall survival (OS). Study participants included 66 patients with pancreatic adenocarcinoma who had undergone pretreatment combined FDG positron-emission tomography (PET)/CT imaging and subsequent curative or palliative treatment. Notable positive associations were found between attenuation and mean standardized uptake values of both SAT and VAT. Attenuation and FDG uptake of adipose tissue were remarkably linked with heterogeneity factor and T stage. It was finally confirmed that attenuation of SAT and VAT, and FDG uptake of VAT were correlated significantly with OS after adjusting for age, sex, body mass index, TNM stage, and total lesion glycolysis.
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