Karpathiou G, et al. - Researchers studied 266 subjects with laryngeal and pharyngeal squamous cell carcinomas to investigate the prognostic and predictive role of tumor budding activity (BA), tumor-stroma ratio (TSR), cell nests size (CNS), and stroma type. They observed that stroma-poor tumors and larger CNS exhibited a good response to induction chemotherapy. They also noted stroma-rich tumors, tumor budding, smaller CNS at core and front area, and fibroblastic stroma type, as adverse prognostic determinants in laryngeal and pharyngeal SCC.