Addeo P, Fattori A, Grunder C, et al. - Researchers aimed at determining the histological prognostic factors following resection of locally advanced (LA) and borderline (BL) pancreatic adenocarcinomas treated by neoadjuvant chemotherapy (NC). They performed a retrospective review of 84 patients with LA (n = 55) and BL (n = 29) adenocarcinomas operated on following NC. A median overall survival of 21.10 months was reported following surgery; 1-, 3-, and 5-year overall survival rates were 73%, 32%, and 20%, respectively. Lymphovascular invasion (LVI) was identified to be an independent prognostic factor for overall survival. Poor response and limited long-term survival were observed in correlation with the persistence of LVI at pathology following resection of LA and BL treated by neoadjuvant chemotherapy.