Ghoorun RA, et al. - Researchers investigated the involvement of FKBP14 in the progression of gastric cancer. They picked the AGS cell line for over-expression analysis and selected the SGC-7901 cell line for knock-down analysis. Transfection of AGS cells was done with an FKBP14 overexpression plasmid (AGS-PLV.O-FLAG). Both cell lines were investigated for the expression pattern of FKBP14 by Western blot and RT-PCR. Further, 70 Chinese patients with gastric cancer were assessed for the expression of FKBP14 using tissue microarrays and these were compared with gastric cancer patients from The Cancer Genome Atlas. High expression of FKBP14 was noted in SGC7901 and these were relatively less expressed in AGS cells. In AGS cells, FKBP14 upregulation was noted to promote migration and invasion and inhibit apoptosis. A suppression in migration and invasion and promotion of apoptosis in the SGC-7901 cell line were observed in correlation to knock-down of FKBP14. Findings suggest often up-regulation of FKBP14 in gastric cancer. Patients usually exhibited worse overall survival in correlation with a high expression of FKBP14. In gastric cancer, FKBP14 is an oncogene, and is a possible biomarker for GC diagnosis, invasion, and prognosis.