Nasioudis D, et al. - Researchers examined a total of 1156 patients diagnosed between 2004 and 2015 with a sex cord - stromal tumors (SCSTs) from the National Cancer Database for the prognostic significance of elevated pre-operative serum CA-125 values. Pre-treatment CA-125 values were elevated in 486 (42%). After controlling for patient age (<50 vs > = 50 yrs), the presence of medical co-morbidities, tumor histology (granulosa vs non-granulosa), size (<10 vs > = 10 cm vs unknown) and the performance of lymphadenectomy, elevated preoperative CA-125 levels were noted to be associated with worse survival in this large cohort of patients with early-stage SCSTs .