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Prognostic significance of blood and lymphatic vessel invasion in pathological stage IA lung adenocarcinoma in the 8th edition of the TNM classification

Lung Cancer Oct 04, 2019

Samejima J, Yokose T, Ito H, et al. - In this retrospective analysis, researchers assessed the prognostic value of blood and lymphatic vessel invasion in p-stage IA lung adenocarcinoma in the 8th edition of the Tumor, Node, Metastasis (TNM) classification. They analyzed overall 306 patients with p-Stage 0-IA lung adenocarcinoma, re-grouped as per the 8th edition of the TNM classification. A median follow-up of 98.0 (range: 10-216) months was performed. They found significant differences in 5-year recurrence-free survival among patients with and without tumor vessel invasion (TVI) in p-stage IA1 and IA2 but not in p-stage IA3. Also, significant differences were evident for 5-year lung cancer-specific survival among those with and without TVI in p-stage IA1 and IA2 but not in p-Stage IA3. In this study, TVI was identified as a prognostic factor in patients with p-stage IA1-2 lung adenocarcinoma, and therefore, P-stage IA1 lung adenocarcinoma without TVI may be categorized as minimally invasive.
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