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Prognostic relevance of regional lymph-node distribution in patients with N1-positive non-small cell lung cancer: A retrospective single-center analysis

Lung Cancer Oct 28, 2019

Eichhorn F, et al. - Researchers sought to validate the International Association for the Study of Lung Cancer proposal of stratification of patients with the limited nodal disease (pN1) from low (pN1a) to high (pN1b) nodal tumor burden via retrospectively analyzing data of 317 patients with pN1 NSCLC treated between January 2012 and December 2016. Observations revealed the association of pN1 in only one region (hilar or lobar) with a better outcome than metastatic affection of both regions after surgery and adjuvant therapy. Only in adenocarcinoma, the prognostic importance of a stratification towards single (pN1a) and multiple (pN1b) N1-metastases was evident. Significant worsening survival in adenocarcinoma was observed in correlation with the increased nodal burden (pN1b, multiple zone involvement). They recommend giving consideration to nodal count and histology as prognostic factors in N1 NSCLC in future TNM-classifications
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