Arpa G, et al. - This study was undertaken to explore histologically and immunohistochemically 52 Crohn disease-associated small bowel carcinomas (CrD-SBCs) and 51 small bowel carcinomas unrelated to inflammatory disease, together with their tumor-associated mucosa, looking for Crohn-selective changes. They examined histologic patterns and phenotypic markers potentially predictive of CrD-SBC histogenesis and prognosis. This study’s findings demonstrate that the cytokeratin 7 and/or MUC5AC-positive metaplastic foci and the non-conventional growths may have a role in cancer histogenesis, while tumor cytokeratin 7 and non-cohesive histotype may also prognosticate poor patient survival. Current data are worth being considered in further prospective histogenetic and clinical studies.