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Prognostic performance of seven biomarkers compared to liver biopsy in early alcohol-related liver disease

Journal of Hepatology Jun 13, 2021

Rasmussen DN, Thiele M, Johansen S, et al. - Because alcohol is the leading cause of liver-related mortality and morbidity, researchers sought to compare the prognostic performance of elastography and blood-based markers in predicting time to first liver-related event, severe infection, and all-cause mortality in patients with a history of excessive drinking. The sample consisted of patients with early, compensated alcohol-related liver disease. Between April 2013 and September 2018, 462 consecutive patients were included. According to this prospective cohort study, in patients with alcohol-related liver disease, transient elastography, enhanced liver fibrosis test, and 2-dimensional shear-wave elastography are highly accurate prognostic markers. Findings suggested that easy-to-use cut-offs may distinguish between substantially different risk profiles.

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