Zhou Y, Zhang R, Ding Y, et al. - Since there exist few effective tools to personalize as well as adequately assess the prognosis of kidney cancer patients, researchers developed nomograms for overall survival (OS) and cancer-specific survival (CSS) by using a population of 42,890 kidney cancer patients diagnosed in 2005-2011, selected from the Surveillance, Epidemiology, and End Results database. Those who received a diagnosis of kidney cancer in 2012-2015 (n = 24,591) were selected for external validation. The independent risk factors that were incorporated in the nomograms were: age, gender, marital status, surgery, grade, T stage, and M stage. A novel kidney cancer prognostic score system was developed based on the influence of all available variables on survival. In kidney cancer patients, an accurate prediction of 1-, 3-, and 5-year OS and CSS was enabled by the proposed nomograms, as indicated by the favorable area under the curve value, internal, and external validation. A more explicit staging of patients was afforded by the Aggtrmmns prognostic scoring system that was based on age, gender, race, marital status, grade, TNM stage, and surgery of kidney cancer patients, relative to the AJCC staging system. Overall, an effective prediction of OS and CSS in kidney cancer patients can be afforded by the nomogram and Aggtrmmns scoring system, which may assist clinicians to personalize prognostic evaluations as well as clinical decisions.