Han Y, et al. - In this study including 1,070 consecutive and nonselected patients with diffuse large B-cell lymphoma (DLBCL), researchers developed a prognostic nomogram based on the Cox proportional hazards model and compared its performance with that of traditional prognostic schemes. Primary (n = 748) and validation (n = 322) cohorts were used. The nomogram consisted of seven independent prognostic factors (age, Ann Arbor stage, Eastern Cooperative Oncology Group performance status score, lactate dehydrogenase, β2-microglobulin, CD5 expression, and Ki-67 index), identified based on a multivariate analysis of the primary cohort. In the primary cohort and in the validation cohort, 0.77 and 0.76, respectively, was the concordance index (C-index) of the nomogram for overall survival (OS) prediction, better than the international prognostic index (IPI), revised IPI (R-IPI), and National Comprehensive Cancer Network (NCCN)-IPI. With this proposed nomogram, survival of patients with DLBCL, particularly in ptients receiving rituximab plus CHOP (R-CHOP) or R-CHOP-like regimens, was accurately estimated.