Thellier N, Altes A, Appert L, et al. - This study was undertaken to investigate the hypothesis that global longitudinal strain (GLS) magnitude ≤ 15% obtained with vendor-independent speckle-tracking strain software may be able to distinguish individuals with severe aortic stenosis (AS) who are at higher risk of death, despite preserved left ventricular ejection fraction (LVEF) and no or mild symptoms. Researchers retrospectively obtained GLS in 332 patients with severe AS (aortic valve area indexed [AVAi] < 0.6 cm 2/m 2), no or mild symptoms, and LVEF ≥ 50%. They obtained absolute values of GLS. They carried out survival analyses to examine the effect of GLS magnitude on all-cause mortality. The results of this study demonstrate that in this series of patients with severe AS, no or mild symptoms, and LVEF ≥ 50%, GLS obtained with vendor-independent speckle-tracking strain software was an effective tool to distinguish patients with a poor outcome. In patients with severe AS, detection of myocardial dysfunction by identifying GLS magnitude < 15%, no or mild symptoms, and LVEF ≥ 50%, can aid in risk assessment.