Lee JM, et al. - Researchers examined patients with coronary artery disease to assess the link between physiological stenosis severity and coronary computed tomography angiography (CTA)-defined high-risk plaque characteristics (HRPC), as well as to determine the prognostic implications of coronary CTA-defined HRPC by physiological stenosis severity. They analyzed overall 772 vessels (299 patients) assessed by both coronary CTA and fractional flow reserve (FFR). Findings revealed a close association between physiological stenosis severity and the number of HRPC, as well as, a significant association of both components with the risk of clinical events. However, different prognostic implication of HRPC was shown based on FFR. A better prognostic stratification can be ensured, particularly in patients with FFR >0.80, by integrating both physiological stenosis severity and plaque vulnerability rather than either individual component alone.