Zhu Y, Xia X, Gross N, et al. - Using Kaplan-Meier estimates and Cox model, researchers examined significance of HPV16 DNA/p16 for survival of patients with laryngeal squamous cell carcinoma (LSCC). HPV16 DNA and p16 status were determined in 812 patients with LSCC. Adjusted HRs for HPV16 positivity were 0.57, 95% CI, 0.38 to 0.87; 0.60, 0.40 to 0.88; and 0.65, 0.46 to 0.94 for disease-specific survival, recurrence-free survival, and overall survival, respectively, compared with HPV negativity. Findings suggested that HPV16/p16 can affect survival outcomes of LSCC patients, especially in never smokers.