Park J, et al. - In this study including 5,243 patients with ST-segment–elevation myocardial infarction who had primary percutaneous coronary intervention, researchers assessed the influence of onset-to-door (O2D) or door-to-balloon (D2B) time on prognosis (all-cause mortality at 1 year). The median O2D time and the median D2B time was 2.0 hours and 59 minutes, respectively. An independent association of D2B time with mortality was evident in multivariable analysis. Further reduction in the risk of mortality was seen relative to lowering D2B time to within 45 minutes vs D2B time >90 minutes. Continuous lowering of 1-year mortality was demonstrated by every reduction of D2B time by 30 minutes. Overall, there was a significant link between shortening D2B time and survival benefit. Even at <60 to 90 minutes, the benefit for survival seen with shortening D2B time was consistently seen.