Lucarini G, et al. - Researchers examined 54 laryngeal squamous cell carcinoma (LSCC) cases for CEACAM subtype 1 (CEACAM1) expression. In addition, they appraised its combinational clinical significance for the diagnosis or prognosis and treatment decision making in these cases. For the first time, outcomes here demonstrated a correlation of CEACAM1 expression with an adverse prognosis in LSCC. Fifty percent of cases showed positive CEACAM1 expression. Tumor grade, development of local recurrence, node and distant metastasis were noted to be correlated with CEACAM1 expression. As per Kaplan–Meier survival curves, CEACAM1 staining had an inverse correlation to both overall and disease-specific 5-year survival. These findings support CEACAM1 as a relevant biomarker and a promising therapeutic target in LSCC.