Kahlert S, et al. - In this single-center retrospective cohort study, researchers investigated the risk factors for local recurrence after breast-conserving surgery (BCS). They focused especially on the effect of residual disease in specimens of simultaneous additional excisions (AE) from the tumor cavity on patients´ outcome in patients with negative final margin status after one-step BCS. Findings from the current analysis of 1,081 patients suggested an association of residual disease in simultaneous additional excisions with an increased risk for ipsilateral breast tumor recurrence, despite negative final margin status. They recommend considering the findings in the overall therapeutic concept.