Neri S, et al. - In view of the observation that non-small cell lung cancer has poor prognosis in relation to microscopic vessel invasion (MVI) and visceral pleural invasion (VPI), and known malignant phenotypes such as epithelial–mesenchymal transition (EMT) and cancer stemness (CS), induce resistance to cancer therapy, researchers examined the prognostic value of MVI and the correlations among VPI/MVI, EMT, CS, and treatment failure for recurrent tumor. Complete resection was performed in 1034 consecutive patients with pathological T1-4N0-2M0 lung adenocarcinoma from 2002 to 2013. Outcomes indicate that MVI and VPI are independent predictors of overall survival (OS) for these patients. These were noted to be correlated with EMT, CS, and treatment failure for recurrent tumor.