Prognostic impact of home blood pressures for adverse cardiovascular outcomes and mortality in patients with resistant hypertension: A prospective cohort study
Hypertension Sep 30, 2021
Cardoso CRL, Salles GF, et al. - Among patients suffering from resistant hypertension, adverse cardiovascular outcomes and mortality were predicted by higher/uncontrolled home blood pressure (HBP) levels. In such patient population, improved risk discrimination was provided by higher/uncontrolled HBP levels.
A total of 333 patients with resistant hypertension were included.
Patients had 24-hour ambulatory and HBP monitoring done at baseline and were followed up for a median of 5.6 years.
Significantly higher risks of all adverse outcomes were observed in relation to continuous HBP parameters, with hazard ratios varying from 1.7 to 2.1, post-adjustments for office and ambulatory blood pressures (BPs).
Uncontrolled HBP, in dichotomical analyses, was related to significantly higher risks of all outcomes, except for the evening HBP.
The highest risks were observed in relation to morning HBP.
Improved risk discrimination equivalent to that obtained from ambulatory BPs was provided by HBP parameters, except for all-cause and cardiovascular mortalities, in which ambulatory BPs afforded greater improvements vs HBPs.
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