Laribi K, et al. - Researchers performed a retrospective analysis of patients with high risk myelodysplastic syndromes treated with azacytidine (AZA) to assess the prognostic value of serum ferritin (SF) levels at diagnosis in these subjects. They found an association of SF level ≥ 725 ng/ml with worse OS and PFS in multivariate analysis adjusting to other co-variables. They also noted that worse outcome resulted from unfavorable karyotype. A negative influence of SF level on OS was seen, and it was believed that this effect was not only associated with iron toxicity, but most likely considered as a surrogate marker for very ineffective erythropoiesis resulting in marked anemia.